Our internal clocks can become ticking time bombs for diabetes and obesity

Public release date: 1-Apr-2013
[ | E-mail | Share ]

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology

New research in The FASEB Journal using mice suggests that disrupting our internal clocks can lead to a complete absence of 24-hour bodily rhythms and an immediate gain in body weight

If you're pulling and all-nighter to finish a term paper, a new parent up all night with a fussy baby, or simply can't sleep like you once could, then you may be snoozing on good health. That's because new research published in The FASEB Journal used mice to show that proper sleep patterns are critical for healthy metabolic function, and even mild impairment in our circadian rhythms can lead to serious health consequences, including diabetes and obesity.

"We should acknowledge the unforeseen importance of our 24-hour rhythms for health," said Claudia Coomans, Ph.D., a researcher involved in the work from the Department of Molecular Cell Biology in the Laboratory of Neurophysiology at Leiden University Medical Center in Leiden, Netherlands. "To quote Seneca 'We should live according to nature (secundum naturam vivere).'"

To make this discovery, Coomans and colleagues exposed mice to constant light, which disturbed their normal internal clock function, and observed a gradual degradation of their bodies' internal clocks until it reached a level that normally occurs when aging. Eventually the mice lost their 24-hour rhythm in energy metabolism and insulin sensitivity, indicating that relatively mild impairment of clock function had severe metabolic consequences.

"The good news is that some of us can 'sleep it off' to avoid obesity and diabetes," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "The bad news is that we can all get the metabolic doldrums when our normal day/night cycle is disrupted."

###

Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and through collaborative advocacy.

Details: Claudia P. Coomans, Sjoerd A. A. van den Berg, Thijs Houben, Jan-Bert van Klinken, Rosa van den Berg, Amanda C. M. Pronk, Louis M. Havekes, Johannes A. Romijn, Ko Willems van Dijk, Nienke R. Biermasz, and Johanna H. Meijer. Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity. FASEB J. April 2013 27:1721-1732; doi:10.1096/fj.12-210898; http://www.fasebj.org/content/27/4/1721.abstract

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 1-Apr-2013
[ | E-mail | Share ]

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology

New research in The FASEB Journal using mice suggests that disrupting our internal clocks can lead to a complete absence of 24-hour bodily rhythms and an immediate gain in body weight

If you're pulling and all-nighter to finish a term paper, a new parent up all night with a fussy baby, or simply can't sleep like you once could, then you may be snoozing on good health. That's because new research published in The FASEB Journal used mice to show that proper sleep patterns are critical for healthy metabolic function, and even mild impairment in our circadian rhythms can lead to serious health consequences, including diabetes and obesity.

"We should acknowledge the unforeseen importance of our 24-hour rhythms for health," said Claudia Coomans, Ph.D., a researcher involved in the work from the Department of Molecular Cell Biology in the Laboratory of Neurophysiology at Leiden University Medical Center in Leiden, Netherlands. "To quote Seneca 'We should live according to nature (secundum naturam vivere).'"

To make this discovery, Coomans and colleagues exposed mice to constant light, which disturbed their normal internal clock function, and observed a gradual degradation of their bodies' internal clocks until it reached a level that normally occurs when aging. Eventually the mice lost their 24-hour rhythm in energy metabolism and insulin sensitivity, indicating that relatively mild impairment of clock function had severe metabolic consequences.

"The good news is that some of us can 'sleep it off' to avoid obesity and diabetes," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "The bad news is that we can all get the metabolic doldrums when our normal day/night cycle is disrupted."

###

Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and through collaborative advocacy.

Details: Claudia P. Coomans, Sjoerd A. A. van den Berg, Thijs Houben, Jan-Bert van Klinken, Rosa van den Berg, Amanda C. M. Pronk, Louis M. Havekes, Johannes A. Romijn, Ko Willems van Dijk, Nienke R. Biermasz, and Johanna H. Meijer. Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity. FASEB J. April 2013 27:1721-1732; doi:10.1096/fj.12-210898; http://www.fasebj.org/content/27/4/1721.abstract

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/foas-oic040113.php

Kate Middleton Nude Photos glee glee boxing news Coptic Christian saturday night live julio cesar chavez jr

IMF team to arrive in Egypt on Wednesday for loan talks

CAIRO (Reuters) - An International Monetary Fund delegation will arrive in Egypt on Wednesday for talks with the government on a $4.8 billion loan, Egypt's government spokesman Alaa El Hadidi said on Sunday.

More than two years of political upheaval have battered the Egyptian economy, leaving it in dire need of IMF funding to relieve a currency and budget crisis. The country's reserves of foreign currency have fallen to critically low levels, threatening its ability to import essential supplies of fuel and wheat.

President Mohamed Mursi's government initialed a deal with the IMF last November but postponed final ratification in December in the face of unrest triggered by a political row over the extent of his powers.

Hadidi, talking to reporters, gave no details on the new round of talks with the IMF. The IMF said last week a technical delegation would visit Cairo in the "first days of April".

Masood Ahmed, director of the IMF's Middle East and Central Asia department, visited Cairo on March 17, saying the Fund would continue talks aimed at agreeing possible financial aid.

(Writing by Ulf Laessing; Editing by Catherine Evans)

Source: http://news.yahoo.com/imf-team-arrive-egypt-wednesday-loan-talks-103424340--business.html

abraham lincoln vampire hunter their eyes were watching god lara logan manu ginobili sports illustrated swimsuit 2012 aretha franklin whitney houston paul williams

Ericsson T28z review

When Ericsson launched the T28 in 1999, it was the lightest and slimmest phone on the market. It was also the first handset ever to use a lithium polymer battery. The T28 was a premium device -- Ericsson described it as "designer technology", and it was successful with business executives before the Blackberry became popular. Unlike its bar-shaped competitors, the T28 was immediately recognizable by its signature antenna stub and "active flip" keypad cover. Ericsson packed the phone with state-of-the-art features like voice dialing and an optional Bluetooth dongle. It came in three versions: T28s (GSM 1800 / 900), T28z (GSM 1900) and T28 World (GSM 1900/900). Our T28z review unit started life on VoiceStream (eventually acquired by T-Mobile). How does this classic handset stack up to our modern pocketable computers? Find out after the break.

Filed under: Cellphones, Mobile

Comments

Source: http://www.engadget.com/2013/04/01/ericsson-t28z-review/

grammys 2012 deadmau5 phoebe snow jennifer hudson tribute to whitney houston nicki minaj grammy jason whitlock beach boys

UCLA hires Steve Alford as new basketball coach

LOS ANGELES (AP) ? Steve Alford was hired as UCLA basketball coach on Saturday, spurning New Mexico days after he agreed to a new 10-year deal with the Lobos for a chance to run what he called "the premier basketball program in the country."

The Bruins are bringing in someone who shares the same Indiana roots as John Wooden, who led UCLA to a record 10 national championships, including seven in a row, before retiring in 1975. Alford learned about Wooden as a first-grader in Martinsville, Ind., where his father, Sam, coached the high school basketball team at Wooden's alma mater.

"Ever since then there was a draw to find out more about him," Alford said on a teleconference. "I know my first steps into Pauley I will really feel that."

Alford agreed to a seven-year deal worth $18.2 million, with a yearly salary of $2.6 million and a $200,000 signing bonus, according to UCLA athletic director Dan Guerrero.

Alford will be introduced in Westwood on Tuesday.

"This is truly a leap of faith," he said.

Guerrero said UCLA reached out to Alford first, not knowing whether he would be interested in the Bruins. Once he confirmed he was, the details were finalized early Saturday, Guerrero said.

"It was not an easy decision because I was extremely happy," Alford said. "I was about as happy as I can be.

"When I kept thinking about things, it still came back to UCLA. You're talking about the premier basketball program in the country. To have an opportunity like this, they don't come around every day."

Guerrero said Alford is "the perfect fit for UCLA" because he connects with a new generation of players and brings an up-tempo and team-oriented style of play to Westwood.

"He's ready for this stage," Guerrero said.

Alford's deal with New Mexico, scheduled to take effect on April 1, was worth more than $20 million over 10 years.

Guerrero said Alford is responsible for a buyout of his agreement in Albuquerque, but that UCLA would work out the details. Both Alford and New Mexico athletic director Paul Krebs said they didn't know how much the buyout was worth.

Alford, who is 48, succeeds Ben Howland, who was fired last weekend after 10 years and a 233-107 record that included three consecutive Final Four appearances and four Pac-12 titles. The Bruins were 25-10 this season, which ended with a 20-point loss to Minnesota in the second round of the NCAA tournament.

Alford led New Mexico to a 29-6 record this season that included the Mountain West regular-season and tournament titles. But the Lobos were upset by Harvard in the second round of the NCAAs shortly after Alford's new contract had been announced.

Alford had a 155-52 record in six years at New Mexico, with the Lobos making three trips to the NCAA tournament. He was selected Mountain West coach of the year three times.

"I'm about building programs, not teams, not seasons," Alford said. "UCLA doesn't just want one winning season, UCLA wants a basketball program that is going to breed consistent excellence.

"I've always tried to do things with excellence. When you think of UCLA in every regard, you see the word excellence."

Expectations have always been high in Westwood since Wooden's era. The Bruins own a record 11 national championships, but have won just one ? in 1995 under Jim Harrick ? since Wooden retired.

"Nobody understands pressure any more than I do. I've been under pressure since I was 16," said Alford, whose high school gym in New Castle, Ind., seats 10,000 and frequently sold out when he was there. "You're not going to find anybody more competitive than I am."

Guerrero said, "He's not the kind of guy that will shy away from what UCLA basketball is all about."

The Lobos didn't just lose Alford, they also won't have his son, Bryce, on their roster next season. Alford said his highly touted son would follow him to Westwood, continuing a tradition that Alford first established when he played under his father at New Castle Chrysler High.

Krebs said it was clear when he talked to Alford on Saturday morning that his mind was made up, and although he's disappointed, he said he respected the decision.

Krebs said it was like a "bomb dropped in the room" when Alford told his players he was leaving.

"This is a very emotional time," Krebs said. "There is no good way to break the news to the young men in the program. ... There's a lot of raw emotion right now."

Alford said, "That's not easy to look those young men in the face, but I think they understand. The reason they understand is it's UCLA. If it was anywhere else, this is not a decision that would have been made."

Lobos senior center Alex Kirk said, "Nobody would say no to UCLA. That's crazy."

Guerrero had said he wanted a coach who would help boost season ticket sales. The Bruins had just a few sellouts at newly renovated Pauley Pavilion this season.

"I think the UCLA family will embrace him. I think he'll be able to hit on all cylinders," Guerrero said. "He'll be able to energize the fan base in so many ways. Look at New Mexico, they get 15,000 a game. It's madness there."

Alford is known for his up-tempo coaching style, which should suit Bruins fans turned off by Howland's grind-it-out defensive emphasis.

"We do like to score points, we like transition, we like to get up and down the floor," he said, while noting that defense wins championships. "Ultimately, it's about the product ? are they good young men of character and integrity?"

Alford called recruiting in fertile Southern California "of the utmost importance." He had players from the region on his New Mexico roster, including Kendall Williams, who became Mountain West player of the year.

"I will hit the ground running," he said, noting the respect he has for high school coaches was formed through his father.

Alford's other head coaching stints were at Iowa (2000-07), Missouri State (1996-99) and Manchester College (1992-95) in Indiana.

Alford is famous in the Hoosier state, where he starred at Indiana University from 1984-87 under coach Bob Knight. The Hoosiers won the national championship in his senior year. He also played on the gold medal-winning 1984 U.S. Olympic basketball team in Los Angeles as a college sophomore. Knight coached that team. Alford said he put in a call to his former coach about taking the UCLA job.

Alford was drafted by the Dallas Mavericks in 1987 and played four years in the NBA before starting his head coaching career at tiny Division III Manchester.

As a high school senior, Alford averaged 37.7 points and was Indiana Mr. Basketball.

Besides Bryce, Alford and his wife, Tanya, have a son, Kory, and a daughter, Kayla.

___

Associated Press Writer Susan Montoya Bryan in Albuquerque contributed to this report.

Source: http://news.yahoo.com/ucla-hires-steve-alford-basketball-coach-162919050--spt.html

shroud of turin the borgias the masters warren sapp i robot the big c the visitor

Measure Your Feet and Hands to Judge Distance Accurately Without a Ruler

Nobody carries a ruler with them everywhere, but you can measure short distances accurately if you memorize the lengths of your feet and hand span.

Quora user Peter Baskerville suggests measuring your appendages, and committing them to memory.

Learning the actual measurement of your span and your foot will help you whenever your need to measure something but don't have access to a ruler or tape measure. You can then measure anything by number of spans or feet (toe to heel). Then multiply the spans or feet by the known measurement to estimate fairly accurately the actual length, depth or breadth of things.

For other measurements, you could use the same trick with the distance between the tip of your thumb and its first knuckle, or the distance between your nose and your thumb with your arm outstretched. If you have a poor memory, you could always store the lengths in something like Evernote too. This tip is pretty obvious in hindsight, but it's worth mentioning if you haven't done it.

Learning: What is something useful I can learn right now in 10 minutes that would be useful for the rest of my life? | Quora

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ZT2Gwq6NHSs/measure-your-feet-and-hands-to-judge-distance-accurately-without-a-ruler

taco bell taco bell Breezy Point Seaside Heights nj transit PSEG hocus pocus

Alaska Troopers helicopter crashes during rescue

ANCHORAGE, Alaska (AP) ? An Alaska State Trooper helicopter carrying two troopers and a rescued snowmobiler crashed Saturday night in the south-central part of the state, and no survivors have been found, an agency spokeswoman said.

Trooper spokeswoman Megan Peters said the crash site was spotted Sunday, but she could not immediately confirm that the three on board were killed.

Wreckage of the helicopter burned, but Peters said it was not known how the fire started or how long it lasted.

The trooper helicopter was on a mission to pick up a snowmobiler stranded near Larson Lake 7 miles east of Talkeetna in the Matanuska-Susitna Borough.

The helicopter picked up a trooper and began a search, spotting the snowmobile and landing just before 10 p.m. It took off with the snowmobiler and was supposed to meet medics near Talkeetna but did not arrive.

The National Weather Service said the temperature in Talkeetna Sunday night was 34 with light rain that turned into snow at about 11 p.m., but that visibility was 10 miles.

Peters said it's not known if weather was a factor in the crash. The National Transportation Safety Board will investigate.

Alaska Air National Guard helicopter spokeswoman Kalei Rupp said fog in Anchorage and mandatory crew rest kept an agency helicopter from launching until 5 a.m.

A guard helicopter spotted the wreckage at 9:20 a.m. Sunday and landed.

Talkeetna is a community of nearly 900 about 80 miles north of Anchorage. It's the primary departure point for air taxis taking climbers to Mount McKinley.

The crash site was near the south end of Larson Lake.

The Alaska State Troopers have had at least one officer die in a helicopter crash during a search and rescue mission.

Trooper John David Stimson was on a chartered helicopter in 1983 that was attempting to reach a downed pilot in a blizzard. The chartered helicopter crashed near Cordova.

Stimson survived and assisted pilot Gary Wiltrout, who had suffered a broken back. However, when rescuers reached the crash site after 24 hours, the 11-year trooper had died of exposure. Wiltrout survived.

Source: http://news.yahoo.com/alaska-troopers-helicopter-crashes-during-rescue-001713287.html

jason wu Mavericks Surf Stonewall Inaugural Ball julio jones j crew san francisco 49ers

John Walsh?s ?America?s Most Wanted?

John Walsh’s “America’s Most Wanted”

The Lifetime network has cancelled “America?s Most Wanted”, which has brought home over 50 missing children and landed over 1,000 fugitives to justice all over the world. The show, hosted by John Walsh, was picked up by Lifetime in December 2011. There is hope “America’s Most Wanted” will be picked up by another network. TV ...

John Walsh’s “America’s Most Wanted” Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/03/john-walshs-americas-most-wanted/

steve jobs fbi file suge knight obama birth control mortgage settlement macauly culkin joe namath stefon diggs